Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis
Abstract The MRE11-RAD50-NBS1/Xrs2 (MRN/X) protein complex has ribavirin coupon essential roles in the repair of damaged DNA.The current understanding of the conformational landscape of the core MR complex comes from various structural studies.However, given the heterogeneous nature of these structures, we suspect that several conformational states